7,500 X 24 hours…
processing.... var drug_clName=["Anticoagulants, Cardiovascular","Anticoagulants, Hematologic"];var drug_clID=["99","230"];var drug_brName=[];var drug_brID=[]; Drugs & Diseasesheparin (Rx)Brand and Other Names:Classes: Anticoagulants, Cardiovascular;
Anticoagulants, Hematologic
ShareEmailPrintFeedbackCloseFacebookTwitterLinkedInWhatsAppwebmd.ads2.defineAd(id: 'ads-pos-421',pos: 421);webmd.ads2.defineAd(id: 'ads-pos-2017',pos: 2017); SectionsSections heparinDosing & UsesInteractionsAdverse EffectsWarningsPregnancyPharmacologyAdministrationImagesPatient HandoutFormularyDosing & UsesAdultPediatricDosage Forms & Strengths heparin lock solution 1unit/mL
2units/mL
10units/mL
100units/mL
injectable solution 1000units/mL
2500units/mL
5000units/mL
10,000units/mL
20,000units/mL
premixed IV solution 12,500units/250mL
20,000units/500mL
25,000units/250mL
25,000units/500mL
DVT & PE Prophylaxis 5000 units SC q8-12hr, OR
7500 units SC q12hr
Treatment 80 units/kg IV bolus, THEN continuous infusion of 18 units/kg/hr, OR
5000 units IV bolus, THEN continuous infusion of 1300 units/hr, OR
250 units/kg (alternatively, 17,500 units) SC, THEN 250 units/kg q12hr
Dosing considerations Numerous concentrations available; extreme caution is required to avoid medication error
Acute Coronary Syndromes PCI Without GPIIb/IIIa inhibitor: Initial IV bolus of 70-100 units/kg (target ACT 250-300 sec)
With GPIIb/IIIa inhibitor: Initial IV bolus of 50-70 units/kg (target ACT >200 sec)
STEMI Patient on fibrinolytics: IV bolus of 60 units/kg (max: 4000 units), THEN 12 units/kg/hr (max 1000 units/hr) as continuous IV infusion
Dose should be adjusted to maintain aPTT of 50-70 sec
Unstable Angina/NSTEMI Initial IV bolus of 60-70 units/kg (max: 5000 units), THEN initial IV infusion of 12-15 units/kg/hr (max: 1000 units/hr)
Dose should be adjusted to maintain aPTT of 50-70 sec
Dosing considerations Numerous concentrations available; extreme caution is required to avoid medication error
Anticoagulation Intermittent IV injection 8000-10,000 units IV initially, THEN 50-70 units/kg (5000-10,000 units) q4-6hr
Continuous IV infusion 5000 units IV injection, followed by continuous IV infusion of 20,000-40,000 units/24 hr
Dosing considerations Numerous concentrations available; extreme caution is required to avoid medication error
Heparin sodium may prolong one-stage prothrombin time; when heparin sodium is given with dicumarol or warfarin sodium, a period of at least 5 hr after last intravenous dose or 24 hr after last subcutaneous dose should elapse before blood is drawn if a valid prothrombin time is to be obtained
Catheter Patency Prevention of clot formation within venous and arterial catheters
7,500 x 24 hours…
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Because clinical symptoms of end-organ toxicity do not manifest until 24 to 48 hours after acute ingestion, most patients with acetaminophen overdose will be asymptomatic initially. This makes the time of ingestion, the quantity, and the formulation of acetaminophen ingested extremely important for diagnosis of liver toxicity.3,5
NAC is maximally hepatoprotective when administered within 8 hours of acute acetaminophen ingestion. When indicated, however, NAC should be administered regardless of the time elapsed since the overdose. Therapy with NAC has been shown to decrease mortality rates in late-presenting patients with hepatic failure, even in the absence of measurable serum APAP levels.6
The evaluation of an IV acetaminophen overdose is similar to that of an oral overdose.1 Because antidotal therapy is most effective when initiated within 8 hours after an ingestion, it is important to obtain an accurate history of the time(s) of ingestion, the quantity of acetaminophen, and the formulation of acetaminophen ingested. This will reduce the risk of hepatotoxicity.2
Pharmacokinetics: Ingested acetaminophen is rapidly absorbed from the stomach and small intestine. The serum concentration peaks 1 to 2 hours post ingestion. Therapeutic levels are 5 to 20 mcg/mL (33-132 µmol/L). Peak plasma levels occur within 4 hours after ingestion of an overdose of an immediate-release preparation. Ingestion of an acetaminophen extended-release formulation may result in the achievement of peak serum levels >4 hours post ingestion.8 Generally, the elimination half-life of acetaminophen is 2 hours (range 0.9-3.25 hours). In patients with underlying hepatic dysfunction, the half-life may last as long as 17 hours post ingestion.
The Rumack-Matthew nomogram (or, acetaminophen-toxicity nomogram) plots the serum acetaminophen concentration against the time since ingestion to predict possible liver toxicity, as well as allow the clinician to decide whether to proceed with NAC treatment. It is a logarithmic graph starting not directly from ingestion, but from 4 hours post ingestion, after absorption is considered likely to be complete. This nomogram allows for the timely management of acetaminophen overdose. Generally, a serum plasma APAP concentration of 140-150 mcg/mL at 4 hours post ingestion indicates the need for NAC treatment.7,10 NAC is approximately 100% hepatoprotective when it is given within 8 hours after an acute acetaminophen ingestion. NAC is approved for both oral and IV administration.
Oral NAC: The FDA-approved regimen for oral administration of NAC (Mucomyst) is as follows: Dilute the 20% solution 1:3 with cola, orange juice, or another soft drink to prepare a 5% solution. Use within 1 hour of preparation for a total treatment of 72 hours.
Solution for IV Injection: For the loading dose, dilute 150 mg/kg (maximum 15 g) in 5% dextrose in water (D5W) 200 mL and infuse over 60 minutes. For the second dose, dilute 50 mg/kg (maximum 5 g) in D5W 500 mL and infuse over 4 hours. For the third dose, dilute 100 mg/kg (maximum 10 g) in D5W 1,000 mL and infuse over 16 hours. To avoid fluid overload in patients weighing
The initial manifestations of acetaminophen poisoning are often mild and nonspecific, and they do not reliably predict subsequent hepatotoxicity. Acetaminophen is rapidly and completely absorbed from the GI tract. Serum concentrations peak between 30 minutes and 2 hours after an oral therapeutic dose. Acetaminophen-induced hepatitis is acute in onset and progresses rapidly. Therefore, measurement of the serum acetaminophen concentration is critical whenever overdose is suspected.
The risk of toxicity is best predicted by relating the time of ingestion to the serum acetaminophen concentration. Therapeutic serum concentrations range from 10 mcg/mL to 20 mcg/mL. Following a single acute overdose of an immediate-release preparation, a serum acetaminophen concentration should be drawn 4 hours after reported ingestion. If the ingestion occurred >4 hours prior to presentation, the concentration should be drawn immediately. The level should be evaluated, according to the Rumack-Matthew nomogram, to determine the need for treatment with NAC.
Now as an added protection in the ongoing battle with bacteria, Pedigo offers side rails made from CuVerro bactericidal copper alloy. Copper is an intrinsic bactericidal element and CuVerro is the only solid touch surface metal registered by the EPA to continuously kill bacteria1 that cause infections and pose a risk to human health. Lab tests show more than 99.9% of bacteria1 associated with disease and infection, including MRSA1, are killed within two hours when in contact with copper. Bacteria will continue to be killed 24 hours a day, week after week, between regular cleanings.
You should not eat or drink for six to eight hours before the test. The test takes place in a hospital, and you will be asked to wear a hospital gown. Sometimes, you will need to spend the night before the test in the hospital. Otherwise, you will come to the hospital the morning of the procedure.Your healthcare provider will explain the procedure and its risks. A witnessed, signed consent form for the procedure is required.Tell your doctor if you:
Holter monitoring is a continuous recording of your ECG, usually for 24 hours, while you go about your usual daily activities. It is especially useful in diagnosing abnormal heart rhythms. The Holt er monitor itself is a small, portable cassette recorder, worn on a strap over the shoulder. Several electrodes (small sticky patches) are placed on your chest and connected by wires to the recorder.
Payments to HTPN can be made over the phone with our automated phone payment system 24 hours a day, seven days a week. All payments made via the automated phone payment system will post the next business day. Please call 1.866.377.1650.
Plastic storage bags designed to optimize O2 and CO2 transfer to preserve platelets for 7 days prior to transfusion were studied in vivo and in vitro. Platelets stored 7 days in second-generation CLX bags were compared to platelets stored 3 days in standard (CL-3861) 3-day storage bags and platelets transfused within 24 hours of collection. The CLX bags maintained concentrate pH at a mean of 6.85 +/- 0.03 (SEM) after 7 days, while in standard bags after 3 days of storage, the mean pH was 6.46 +/- 0.03. A smaller proportion of platelets stored 7 days in CLX bags were discarded because of a pH less than 6.0 compared to those stored 3 days in CL-3861 bags (10 vs 21%). Poststorage pH showed strong correlation with concentrate platelet count and weak correlation with concentrate white cell count in both bag types. There was no significant difference in the mean corrected platelet count increments between platelets stored 7 days in second generation CLX bags and those stored 3 days in CL-3861 bags (10,000 and 12,200 at 1 hour, and 7000 and 7500 at 24 hours, respectively) following transfusion to 16 thrombocytopenic recipients. However, transfusion of fresh platelets achieved mean corrected increments at both 1 and 24 hours posttransfusion that were higher than seen with either group of stored platelets (20,100 at 1 hour and 10,800 at 24 hours). Platelets can be stored 7 days in second-generation CLX blood bags with results comparable to those of platelets stored 3 days in standard bags. 350c69d7ab
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